Article
Decreased expression levels of Ifi genes is associated to the increased resistance to spontaneous arthritis disease in mice deficiency of IL-1RA.
BMC immunology - 2 Aug 2016
Liu Xiaoyun, Jiao Yan, Cao Yanhong, Deng Nan, Ma Yonghui, Hasty Karen A, Kang Andrew, Chen Hong, Stuart John M, Gu Weikuan
Abstract excerpt
BACKGROUND: The mouse strain BALB/c deficient in IL-1 receptor antagonist protein (Il-1ra) develops spontaneous arthritis disease (SAD) while the strain DBA/1 IL1rn (-/-) with the same deficiency does not. Previously, we mapped a QTL on chromosome 1 for SAD and then developed a congenic mouse strain BALB.D1-1(-/-) that contains the QTL genomic fragment associated with resistance from DBA/1(-/-) on a BALB/c(-/-)...
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