Article
p53 gene mutations in soft-tissue sarcomas--correlations with p53 immunohistochemistry and DNA ploidy.
Journal of cancer research and clinical oncology - 1 Jan 1997
Schneider-Stock R, Radig K, Oda Y, Mellin W, Rys J, Niezabitowski A, Roessner A
Abstract excerpt
The significance of p53 mutations in a group of 67 soft-tissue tumors was examined using single-strand conformation polymorphism and direct sequencing analysis. Molecular findings were correlated with immunohistochemical detection of the p53 protein and DNA ploidy status. Mutations of the p53 gen...
Topics
- Adult
- Aged
- Aged, 80 and over
- DNA, Neoplasm
- Female
- Genes, p53
- Humans
- Immunohistochemistry
- Male
- Middle Aged
- Mutation
- Ploidies
- Polymorphism, Single-Stranded Conformational
- Prognosis
- Sarcoma
- Soft Tissue Neoplasms
- Tumor Suppressor Protein p53