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Article

Prognostic implications of p53 nuclear overexpression and high proliferation index of Ki-67 in adult soft-tissue sarcomas.

Journal of the National Cancer Institute - 6 Apr 1994

Drobnjak M, Latres E, Pollack D, Karpeh M, Dudas M, Woodruff J M, Brennan M F, Cordon-Cardo C

Abstract excerpt

BACKGROUND: Morphologically similar soft-tissue sarcomas may behave in very different fashions, making it difficult to predict clinical outcomes and to properly design therapeutic interventions. In a preliminary study, we observed that TP53 mutations and nuclear overexpression of p53 protein were frequent events in soft-tissue sarcoma, and we noticed an association between p53-positive phenotype and poor clinical...

Topics

Adult
Antibodies, Monoclonal
Gene Expression
Humans
Immunohistochemistry
Ki-67 Antigen
Neoplasm Proteins
Nuclear Proteins
Phenotype
Predictive Value of Tests
Prognosis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Sarcoma

Survival Analysis

Tumor Suppressor Protein p53

Source

Identifiers

PMID: 8133539
DOI: 10.1093/jnci/86.7.549

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8133539-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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