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Article

Prognostic implications of p53 nuclear overexpression and high proliferation index of Ki-67 in adult soft-tissue sarcomas.

Journal of the National Cancer Institute - 6 Apr 1994

Drobnjak M, Latres E, Pollack D, Karpeh M, Dudas M, Woodruff J M, Brennan M F, Cordon-Cardo C

Abstract excerpt

BACKGROUND: Morphologically similar soft-tissue sarcomas may behave in very different fashions, making it difficult to predict clinical outcomes and to properly design therapeutic interventions. In a preliminary study, we observed that TP53 mutations and nuclear overexpression of p53 protein were frequent events in soft-tissue sarcoma, and we noticed an association between p53-positive phenotype and poor clinical...

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Identifiers

PMID: 8133539
DOI: 10.1093/jnci/86.7.549

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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