Article
p53 expression and its relationship to DNA alterations in bone and soft tissue sarcomas.
British journal of cancer - 1 Dec 1993
Wadayama B, Toguchida J, Yamaguchi T, Sasaki M S, Yamamuro T
Abstract excerpt
The p53 gene is one of the best studied tumour suppressor genes. Recently we performed mutation analysis on the p53 gene in a large number of bone and soft tissue sarcomas, and found that approximately one-third of the sarcomas have some type of DNA alteration at the p53 locus (Toguchida et al., 1992). However, the expression of the p53 protein resulting from these alterations still remains to be clarified. In...
Topics
- Base Sequence
- Bone Neoplasms
- Chondrosarcoma
- DNA Damage
- DNA Mutational Analysis
- DNA, Neoplasm
- Frameshift Mutation
- Gene Expression Regulation, Neoplastic
- Genes, p53
- Histiocytoma, Benign Fibrous
- Humans