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Article

High prevalence of p53 exon 4 mutations in soft tissue sarcoma.

Cancer - 1 Jun 2007

Das Parimal, Kotilingam Dhanasekaran, Korchin Borys, Liu Jeuhui, Yu Dihua, Lazar Alexander J, Pollock Raphael E, Lev Dina

Abstract excerpt

BACKGROUND: p53 is the most commonly mutated gene in cancer, including soft tissue sarcoma (STS). The authors characterized p53 alterations (protein accumulation and gene mutation) in STS to evaluate possible associations with patient outcomes. METHODS: Thirty-one STS specimens (multiple histologies) were analyzed by p53 immunohistochemistry (IHC) and direct DNA sequencing of p53 exons 2-11 and then correlated...

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Source

Identifiers

PMID: 17429838
DOI: 10.1002/cncr.22680

Genes

STS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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