Evidence for the effect of gender on activity of (S)-mephenytoin 4'-hydroxylase (CYP2C19) in a Chinese population.

doi:10.1097/00008571-199704000-00004

Back to search

Article

Evidence for the effect of gender on activity of (S)-mephenytoin 4'-hydroxylase (CYP2C19) in a Chinese population.

Pharmacogenetics - 1 Apr 1997

Xie H G, Huang S L, Xu Z H, Xiao Z S, He N, Zhou H H

Abstract excerpt

There is evidence that the sex-dependent expression of individual forms of the human cytochrome P450s (CYPs) results in gender-related differences in the hepatic metabolism of certain drugs. Previous work has shown that conflicting evidence exists relating to the sex differences in the activity o...

Topics

Adolescent
Adult
Aryl Hydrocarbon Hydroxylases
Asian People
China
Cytochrome P-450 CYP2C19
Cytochrome P-450 Enzyme System
Female
Genotype
Humans
Male
Mephenytoin
Middle Aged
Mixed Function Oxygenases
Phenotype
Sex Characteristics

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.