Article
Metabolic disposition of lansoprazole in relation to the S-mephenytoin 4'-hydroxylation phenotype status.
Clinical pharmacology and therapeutics - 1 May 1997
Sohn D R, Kwon J T, Kim H K, Ishizaki T
Abstract excerpt
OBJECTIVE: To assess the possible involvement of CYP2C19 in the metabolism of lansoprazole in vivo. METHODS: Sixteen male Korean subjects, who had been phenotyped as extensive metabolizers and poor metabolizers of S-mephenytoin 4'-hydroxylation polymorphism (n = 8 each) with racemic mephenytoin w...
Topics
- 2-Pyridinylmethylsulfinylbenzimidazoles
- Administration, Oral
- Adult
- Anticonvulsants
- Aryl Hydrocarbon Hydroxylases
- Chromatography, High Pressure Liquid
- Cytochrome P-450 CYP2C19
- Cytochrome P-450 Enzyme System
- Drug Interactions
- Enzyme Inhibitors
- Humans
- Hydroxylation
- Korea
- Lansoprazole
- Male
- Mephenytoin
- Mixed Function Oxygenases
- Omeprazole