Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

CYP2C19 genotype determines enzyme activity and inducibility of S-mephenytoin hydroxylase.

Clinica chimica acta; international journal of clinical chemistry - 1 Nov 2001

Zhou H H

Abstract excerpt

BACKGROUND: The association between decreased drug clearance and decreased activity of cytochrome P4502C19 (CYP2C19), the inherited nature of the deficiency, and its frequency and clinical importance were evaluated extensively in the past over one decade. There is an interethnic difference in the frequency of poor metabolizers and mutant alleles of CYP2C19 among Chinese nationalities. Different frequency of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aryl Hydrocarbon Hydroxylases
Share to Cytochrome P-450 CYP2C19
Share to Cytochrome P-450 Enzyme System

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Enzyme Induction

Share to Hydroxylation

Share to Methylation

Share to Mixed Function Oxygenases

Share to Polymorphism, Genetic

Source

Identifiers

PMID: 11694260
DOI: 10.1016/s0009-8981(01)00696-9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

CYP2C19 genotype determines enzyme activity and inducibility of S-mephenytoin hydroxylase.PMID 11694260Read ↗

Genetic variations of S-mephenytoin 4'-hydroxylase (CYP2C19) in the Chinese population.Semantic proximity Read ↗

CYP2C9 polymorphisms and phenytoin metabolism: implications for adverse effects.Semantic proximity Read ↗

CYP2C19 genotype and S-mephenytoin 4'-hydroxylation phenotype in a Chinese Dai population.Semantic proximity Read ↗

The effects of genetic polymorphisms of CYP2C9 and CYP2C19 on phenytoin metabolism in Japanese adult patients with epilepsy: studies in stereoselective hydroxylation and population pharmacokinetics.Semantic proximity Read ↗

In Vitro Functional Characterisation of Cytochrome P450 (CYP) 2C19 Allelic Variants CYP2C19*23 and CYP2C19*24.Semantic proximity Read ↗

From genes to drugs: CYP2C19 and pharmacogenetics in clinical practiceSemantic proximity Read ↗

CYP2C19 genotype-phenotype correlation: current insights and unanswered questionsSemantic proximity Read ↗

The influence of St John's Wort on CYP2C19 activity with respect to genotype.Semantic proximity Read ↗

Influence of the CYP2C9 AND CYP2C19 polymorphisms on phenytoin hydroxylation in healthy individuals from south India.Semantic proximity Read ↗

The role of pharmacogenetics in the metabolism of antiepileptic drugs: pharmacokinetic and therapeutic implications.Semantic proximity Read ↗

Meta-analysis of the population and phenotypic expression of CYP2C9/2C19 polymorphism on drug metabolism in different ethnicitiesSemantic proximity Read ↗

Evaluation of the effects of 20 nonsynonymous single nucleotide polymorphisms of CYP2C19 on S-mephenytoin 4'-hydroxylation and omeprazole 5'-hydroxylation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.