Article
Genetic analysis of the S-mephenytoin polymorphism in a Chinese population.
Clinical pharmacology and therapeutics - 1 Oct 1995
de Morais S M, Goldstein J A, Xie H G, Huang S L, Lu Y Q, Xia H, Xiao Z S, Ile N, Zhou H H
Abstract excerpt
The 4'-hydroxylation of S-mephenytoin exhibits a polymorphism in humans, with the poor metabolizer phenotype exhibiting a lower frequency in white (3% to 5%) than in Oriental populations (13% to 23%). Two mutations in CYP2C19 (CYP2C19m1 and CYP2C19m2) have recently been described that account for...
Topics
- Adolescent
- Adult
- Aryl Hydrocarbon Hydroxylases
- Base Sequence
- Child
- China
- Cytochrome P-450 CYP2C19
- Cytochrome P-450 Enzyme System
- Female
- Genotype
- Humans
- Introns
- Male
- Mephenytoin
- Middle Aged
- Mixed Function Oxygenases
- Molecular Sequence Data
- Phenotype