Article
Genetic analysis of the S-mephenytoin polymorphism in a Chinese population.
Clinical pharmacology and therapeutics - 1 Oct 1995
de Morais S M, Goldstein J A, Xie H G, Huang S L, Lu Y Q, Xia H, Xiao Z S, Ile N, Zhou H H
Abstract excerpt
The 4'-hydroxylation of S-mephenytoin exhibits a polymorphism in humans, with the poor metabolizer phenotype exhibiting a lower frequency in white (3% to 5%) than in Oriental populations (13% to 23%). Two mutations in CYP2C19 (CYP2C19m1 and CYP2C19m2) have recently been described that account for approximately 85% of white and 100% of Japanese poor metabolizers. This study examines whether these mutations account...
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