Genotyping of S-mephenytoin 4'-hydroxylation in an extended Japanese population.

doi:10.1016/S0009-9236(96)90214-3

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Article

Genotyping of S-mephenytoin 4'-hydroxylation in an extended Japanese population.

Clinical pharmacology and therapeutics - 1 Dec 1996

Kubota T, Chiba K, Ishizaki T

Abstract excerpt

OBJECTIVE: To assess the genotype pattern of S-mephenytoin 4'-hydroxylation in an extended Japanese population. METHODS: One hundred eighty-six unrelated, healthy Japanese subjects were genotyped for S-mephenytoin 4'-hydroxylase (CYP2C19) according to a genotyping technique to identify the wild-t...

Topics

Adult
Aryl Hydrocarbon Hydroxylases
Asian People
Cytochrome P-450 CYP2C19
Cytochrome P-450 Enzyme System
Exons
Female
Genotype
Humans
Japan
Male
Middle Aged
Mixed Function Oxygenases
Mutation
Phenotype

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