Article
Myc and Ras collaborate in inducing accumulation of active cyclin E/Cdk2 and E2F.
Nature - 22 May 1997
Leone G, DeGregori J, Sears R, Jakoi L, Nevins J R
Abstract excerpt
Considerable evidence points to a role for G1 cyclin-dependent kinase (CDK) in allowing the accumulation of E2F transcription factor activity and induction of the S phase of the cell cycle. Numerous experiments have also demonstrated a critical role for both Myc and Ras activities in allowing cel...
Topics
- Animals
- CDC2-CDC28 Kinases
- Carrier Proteins
- Cell Cycle Proteins
- Cell Line
- Cyclin-Dependent Kinase 2
- Cyclin-Dependent Kinase Inhibitor p27
- Cyclin-Dependent Kinases
- Cyclins
- DNA-Binding Proteins
- E2F Transcription Factors
- Enzyme Inhibitors
- G1 Phase
- Mice
- Microtubule-Associated Proteins
- Mutation
- Protein Serine-Threonine Kinases
- Proto-Oncogene Proteins c-myc