Article
Myc and Ras collaborate in inducing accumulation of active cyclin E/Cdk2 and E2F.
Nature - 22 May 1997
Leone G, DeGregori J, Sears R, Jakoi L, Nevins J R
Abstract excerpt
Considerable evidence points to a role for G1 cyclin-dependent kinase (CDK) in allowing the accumulation of E2F transcription factor activity and induction of the S phase of the cell cycle. Numerous experiments have also demonstrated a critical role for both Myc and Ras activities in allowing cell-cycle progression. Here we show that inhibition of Ras activity blocks the normal growth-dependent activation of G1...
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