Article
The retinoblastoma protein is linked to the activation of Ras.
Molecular and cellular biology - 1 Nov 1999
Lee K Y, Ladha M H, McMahon C, Ewen M E
Abstract excerpt
The inner membrane-bound protein Ras integrates various extracellular signals that are subsequently communicated from the cytoplasm to the nucleus via the Raf/MEK/MAPK cascade. Here we show that the retinoblastoma protein pRb, previously reported to be a nuclear target of this pathway, can in turn influence the activation state of Ras. Rb-deficient fibroblasts display elevated levels (up to 30-fold) of activated...
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