Article
Cyclin D2 and Ha-Ras transformed rat embryo fibroblasts exhibit a novel deregulation of cell size control and early S phase arrest in low serum.
The EMBO journal - 1 May 1995
Kerkhoff E, Ziff E B
Abstract excerpt
The D-type cyclins are growth factor-regulated delayed early functions which peak at the G1/S transition, are thought to regulate entry into S phase and have been implicated in tumorigenesis. Here, we show that cyclin D2 can co-operate with Ha-Ras to impose a novel transformed state on rat embryo fibroblasts (REF). While clonal cyclin D2/Ha-Ras REF transformants exhibit a characteristic transformed phenotype in...
Topics
- Animals
- Cell Cycle
- Cell Size
- Cells, Cultured
- Culture Media
- Cyclin D2
- Cyclins
- Embryo, Mammalian
- Fibroblasts
- Genes, ras
- Phenotype
- Rats