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Article

Relationship between E1A binding to cellular proteins, c-myc activation and S-phase induction.

Oncogene - 1 Feb 2007

Baluchamy S, Sankar N, Navaraj A, Moran E, Thimmapaya B

Abstract excerpt

We recently showed that p300/CREB-binding protein (CBP) plays an important role in maintaining cells in G0/G1 phase by keeping c-myc in a repressed state. Consistent with this, adenovirus E1A oncoprotein induces c-myc in a p300-dependent manner, and the c-myc induction is linked to S-phase induction. The induction of S phase by E1A is dependent on its binding to and inactivating several host proteins including...

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Identifiers

PMID: 16862175
DOI: 10.1038/sj.onc.1209825

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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