Article
Relationship between E1A binding to cellular proteins, c-myc activation and S-phase induction.
Oncogene - 1 Feb 2007
Baluchamy S, Sankar N, Navaraj A, Moran E, Thimmapaya B
Abstract excerpt
We recently showed that p300/CREB-binding protein (CBP) plays an important role in maintaining cells in G0/G1 phase by keeping c-myc in a repressed state. Consistent with this, adenovirus E1A oncoprotein induces c-myc in a p300-dependent manner, and the c-myc induction is linked to S-phase induction. The induction of S phase by E1A is dependent on its binding to and inactivating several host proteins including...
Topics
- Adenovirus E1A Proteins
- Cell Cycle
- Cell Cycle Proteins
- Cells, Cultured
- Chromatin
- E1A-Associated p300 Protein
- Gene Expression Regulation
- Histone Acetyltransferases
- Humans
- JNK Mitogen-Activated Protein Kinases
- Mutation
- Proto-Oncogene Proteins c-myc
- Retinoblastoma Protein
- S Phase
- Transcription Factors
- Transcription, Genetic
- Transcriptional Activation
- p300-CBP Transcription Factors