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Article

Inhibition of DNA synthesis by RB: effects on G1/S transition and S-phase progression.

Genes & development - 1 Aug 1998

Knudsen E S, Buckmaster C, Chen T T, Feramisco J R, Wang J Y

Abstract excerpt

The retinoblastoma tumor suppressor protein, RB, is a negative regulator of cell proliferation. Growth inhibitory activity of RB is attenuated by phosphorylation. Mutation of a combination of phosphorylation sites leads to a constitutively active RB. In Rat-1 cells, the phosphorylation-site-mutated (PSM)-RB, but not wild-type RB, can inhibit S-phase entry. In PSM-RB-arrested G1 cells, normal levels of cyclin E...

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Identifiers

PMID: 9694794
DOI: 10.1101/gad.12.15.2278
PMCID: PMC317048

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Inhibition of DNA synthesis by RB: effects on G1/S transition and S-phase progression.PMID 9694794Read ↗

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pRB phosphorylation mutants reveal role of pRB in regulating S phase completion by a mechanism independent of E2F.Semantic proximity Read ↗

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The retinoblastoma protein alters the phosphorylation state of polyomavirus large T antigen in murine cell extracts and inhibits polyomavirus origin DNA replication.Semantic proximity Read ↗

Repression of RNA polymerase III transcription by the retinoblastoma protein.Semantic proximity Read ↗

RB reversibly inhibits DNA replication via two temporally distinct mechanisms.Semantic proximity Read ↗

Interchangeable Roles for E2F Transcriptional Repression by the Retinoblastoma Protein and p27KIP1-Cyclin-Dependent Kinase Regulation in Cell Cycle Control and Tumor Suppression.Semantic proximity Read ↗

An Rb-Skp2-p27 pathway mediates acute cell cycle inhibition by Rb and is retained in a partial-penetrance Rb mutant.Semantic proximity Read ↗

Using kinetic studies to uncover new Rb functions in inhibiting cell cycle progression.Semantic proximity Read ↗

Restoration of retinoblastoma mediated signaling to Cdk2 results in cell cycle arrest.Semantic proximity Read ↗

Cyclin D1 Is Dispensable for G <sub>1</sub> Control in Retinoblastoma Gene-Deficient Cells Independently of cdk4 ActivitySemantic proximity Read ↗

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