Article
Active RB elicits late G1/S inhibition.
Experimental cell research - 10 Jun 2002
Angus Steven P, Fribourg Anne F, Markey Michael P, Williams Sarah L, Horn Henning F, DeGregori James, Kowalik Timothy F, Fukasawa Kenji, Knudsen Erik S
Abstract excerpt
The retinoblastoma tumor suppressor protein (RB) is activated/dephosphorylated to mediate cell cycle inhibition in response to antimitogenic signals. To elucidate the mode of RB action at this critical transition, we utilized cell lines that can be induced to express a constitutively active allele of RB (PSM-RB). As expected, induction of PSM-RB, but not wild-type protein (WT), inhibited progression into S phase....
Topics
- Animals
- Cell Cycle Proteins
- Cell Division
- Cell Transformation, Neoplastic
- Cells, Cultured
- Centrosome
- Cyclin A
- Cyclin E
- Cyclin-Dependent Kinases
- Down-Regulation
- Eukaryotic Cells
- G1 Phase
- Gene Expression Regulation, Neoplastic
- Mutation