Article
Rac and Cdc42 are potent stimulators of E2F-dependent transcription capable of promoting retinoblastoma susceptibility gene product hyperphosphorylation.
The Journal of biological chemistry - 24 Jul 1998
Gjoerup O, Lukas J, Bartek J, Willumsen B M
Abstract excerpt
The Rho family of GTPases plays an important and diverse role in reorganization of the actin cytoskeleton, transcriptional regulation, and multiple aspects of cell growth. Our study has examined their potential links to the cell cycle machinery. We find that constitutively active mutants of Rac a...
Topics
- 3T3 Cells
- Animals
- Carrier Proteins
- Cell Cycle Proteins
- Cyclin-Dependent Kinase Inhibitor p16
- Cyclin-Dependent Kinase Inhibitor p21
- Cyclins
- DNA Replication
- DNA-Binding Proteins
- E2F Transcription Factors
- GTP-Binding Proteins
- Genetic Predisposition to Disease
- Mice
- Phosphorylation
- Retinoblastoma Protein
- Retinoblastoma-Binding Protein 1
- Transcription Factor DP1
- Transcription Factors