Article
T cell receptor repertoire diversity and clonal expansion in human neonates.
Pediatric research - 1 Mar 1998
Schelonka R L, Raaphorst F M, Infante D, Kraig E, Teale J M, Infante A J
Abstract excerpt
Newborn human infants, particularly those born prematurely, are susceptible to infection with a variety of microorganisms. We questioned whether limitations in the T cell repertoire contribute to the neonatal immunocompromised state. To describe developmental changes of the T cell repertoire, cDNA segments corresponding to third complementarity regions (CDR3) of human umbilical cord blood T cell receptors (TCR)...
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