Article
Age-related impaired affinity maturation and differential D-JH gene usage in human VH6-expressing B lymphocytes from healthy individuals.
European journal of immunology - 1 Jun 1997
van Dijk-Härd I, Söderström I, Feld S, Holmberg D, Lundkvist I
Abstract excerpt
To elucidate the basic molecular events underlying humoral immunity during ontogeny and senescence, we analyzed a panel of 179 polymerase chain reaction-derived VH6-D-JH rearrangements from cord blood, peripheral blood, and spleen. Nucleotide sequence analysis of the CDR3 region shows that there...
Topics
- Adult
- Aged
- Aging
- Antibody Affinity
- B-Lymphocytes
- Cell Differentiation
- Gene Rearrangement, B-Lymphocyte
- Genes, Immunoglobulin
- Genetic Variation
- Humans
- Immunoglobulin Heavy Chains
- Immunoglobulin Joining Region
- Immunoglobulin Variable Region
- Middle Aged
- Organ Specificity