Article
High frequency of somatically mutated IgM molecules in the human adult blood B cell repertoire.
European journal of immunology - 1 Oct 1992
van Es J H, Meyling F H, Logtenberg T
Abstract excerpt
Nucleotide sequence analysis of cDNA encoded by the single member of the human immunoglobulin VH6 gene family show that blood B cells in adults, but not in neonates, frequently express somatically mutated IgM molecules. The number of mutations in VH6-encoded cDNA from adult blood ranged from 2 to 19 mutations/VH gene (average 10.1/VH gene). The distribution of silent and replacement mutations suggests that at...
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