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Article

Somatic mutation of immunoglobulin V(H)6 genes in human infants.

Clinical and experimental immunology - 1 Oct 1998

Ridings J, Dinan L, Williams R, Roberton D, Zola H

Abstract excerpt

Infants respond to antigen by making antibody that is generally of low affinity for antigen. Somatic hypermutation of immunoglobulin genes, and selection of cells expressing mutations with improved affinity for antigen, are the molecular and cellular processes underlying the maturation of antibody affinity. We have reported previously that neonates and infants up to 2 months of age, including individuals...

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Identifiers

PMID: 9764600
DOI: 10.1046/j.1365-2249.1998.00694.x
PMCID: PMC1905087

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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