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Article

Somatic mutation of immunoglobulin V(H)6 genes in human infants.

Clinical and experimental immunology - 1 Oct 1998

Ridings J, Dinan L, Williams R, Roberton D, Zola H

Abstract excerpt

Infants respond to antigen by making antibody that is generally of low affinity for antigen. Somatic hypermutation of immunoglobulin genes, and selection of cells expressing mutations with improved affinity for antigen, are the molecular and cellular processes underlying the maturation of antibody affinity. We have reported previously that neonates and infants up to 2 months of age, including individuals...

Topics

Adult
Complementarity Determining Regions
Genetic Variation
Humans
Immunoglobulin Heavy Chains
Immunoglobulin Variable Region
Immunoglobulin alpha-Chains
Infant
Mutation

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 9764600
DOI: 10.1046/j.1365-2249.1998.00694.x
PMCID: PMC1905087

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-9764600-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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