Somatic mutation of human immunoglobulin V genes in the X-linked HyperIgM syndrome.

doi:10.1172/JCI117791

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Article

Somatic mutation of human immunoglobulin V genes in the X-linked HyperIgM syndrome.

The Journal of clinical investigation - 1 Mar 1995

Chu Y W, Marin E, Fuleihan R, Ramesh N, Rosen F S, Geha R S, Insel R A

Abstract excerpt

Somatic mutation of Ig variable regions occurs prominently in germinal centers, but it has been debated whether the mutation process initiates in germinal centers or is activated before germinal center entry of B cells. We have analyzed for the presence of somatic mutation in Ig gene rearrangements of the nonpolymorphic human VH6 gene in the X-linked HyperIgM syndrome, which is associated with defective CD40...

Topics

Amino Acid Sequence
Antigens, CD
Antigens, Differentiation, B-Lymphocyte
Autoimmune Diseases
Base Sequence
CD40 Antigens
Gene Rearrangement
Genes, Immunoglobulin
Genetic Linkage
Humans
Immunoglobulin M

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Immunoglobulin Variable Region

Immunologic Deficiency Syndromes

Lymphocytes

Molecular Sequence Data

Mutation

RNA, Messenger

Sequence Homology, Amino Acid

Source

Open in PubMed Open full text

Identifiers

PMID: 7533792
DOI: 10.1172/JCI117791
PMCID: PMC441480

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7533792-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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