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Article

Disrupted IGF2 promoter control by silencing of promoter P1 in human hepatocellular carcinoma.

Cancer research - 15 May 1997

Li X, Nong Z, Ekström C, Larsson E, Nordlinder H, Hofmann W J, Trautwein C, Odenthal M, Dienes H P, Ekström T J, Schirmacher P

Abstract excerpt

Previous investigations have supported or indicated a stimulatory role of the insulin-like growth factor II gene (IGF2) in hepatocarcinogenesis. We have studied the transcript levels, promoter usage, and imprinting status of the ICF2 gene and its relationship to H19 in human hepatocellular carcinomas (HCCs) and liver tumor cell lines. The activity of the IGF2 promoter P1 was lost in about 70% of the cases (18 of...

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Source

Identifiers

PMID: 9158004

Genes

IGF2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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