Altered transcriptional regulation of the insulin-like growth factor 2 gene in human hepatocellular carcinoma.

Article

Altered transcriptional regulation of the insulin-like growth factor 2 gene in human hepatocellular carcinoma.

Molecular carcinogenesis - 1 Apr 1997

Uchida K, Kondo M, Takeda S, Osada H, Takahashi T, Nakao A, Takahashi T

Abstract excerpt

The insulin-like growth factor 2 (IGF2) gene is regulated in a complex manner, involving developmentally regulated use of four different promoters as well as transcriptional repression of the maternal allele due to genomic imprinting. It has been well documented that liver is an exceptional organ...

Topics

Adult
Alleles
Carcinoma, Hepatocellular
Gene Expression Regulation, Neoplastic
Humans
Insulin-Like Growth Factor II
Liver
Liver Neoplasms
Promoter Regions, Genetic
Transcription, Genetic

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