Article
Promoter histone H3K27 methylation in the control of IGF2 imprinting in human tumor cell lines.
Human molecular genetics - 1 Jan 2014
Li Tao, Chen Huiling, Li Wei, Cui Jiuwei, Wang Guanjun, Hu Xiang, Hoffman Andrew R, Hu Jifan
Abstract excerpt
Aberrant imprinting of the insulin-like growth factor II (IGF2) gene is a molecular hallmark of many tumors. Reactivation of the normally suppressed maternal allele leads to upregulation of the growth factor that promotes tumor growth. However, the mechanisms underlying the loss of imprinting (LOI) remain poorly defined. We examined the epigenotypes at the gene promoters that control IGF2 allelic expression....
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