Concordant loss of imprinting of the human insulin-like growth factor II gene promoters in cancer.

doi:10.1074/jbc.270.47.27983

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Article

Concordant loss of imprinting of the human insulin-like growth factor II gene promoters in cancer.

The Journal of biological chemistry - 24 Nov 1995

Zhan S, Shapiro D, Zhan S, Zhang L, Hirschfeld S, Elassal J, Helman L J

Abstract excerpt

The human insulin-like growth factor II (IGFII) gene has been shown to be imprinted for the promoters P2, P3, and P4 but not for the promoter P1 in liver and chondrocytes. Loss of imprinting of the IGFII gene has been found in a variety of human tumors including rhabdomyosarcoma and lung cancer. In this report, we determined whether loss of imprinting in tumors displays a promoter-specific pattern. We examined...

Topics

Adult
Alleles
Base Sequence
Cartilage
Cells, Cultured
DNA Primers
Exons
Genomic Imprinting
Humans
Insulin-Like Growth Factor II
Liver
Lung Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Muscle, Skeletal

Neoplasms

Polymerase Chain Reaction

Promoter Regions, Genetic

Reference Values

Source

Open in PubMed

Identifiers

PMID: 7499276
DOI: 10.1074/jbc.270.47.27983

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7499276-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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