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Article

Hypomethylated P4 Promoter Induces Expression of the <i>Insulin-Like Growth Factor-II</i> Gene in Hepatocellular Carcinoma in a Chinese Population

15 Jul 2006

Abstract excerpt

PURPOSE: The expression of human insulin-like growth factor-II (IGF-II) is regulated by the activation of four promoters (P1-P4) acting in a development-dependent, tissue-specific manner. IGF-II overexpression associated with P3 and P4 activation is observed in animal and human hepatocarcinogenesis. We correlated P4 epigenetic alteration with P4 transcript activation and clinicopathologic features. EXPERIMENTAL...

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PMID: 16857788
DOI: 10.1158/1078-0432.ccr-05-2261

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