Article
Expression, promoter usage and parental imprinting status of insulin-like growth factor II (IGF2) in human hepatoblastoma: uncoupling of IGF2 and H19 imprinting.
Oncogene - 20 Jul 1995
Li X, Adam G, Cui H, Sandstedt B, Ohlsson R, Ekström T J
Abstract excerpt
We have studied the promoter utilization and parental imprinting status of human IGF2 in three genetically informative hepatoblastomas from patients ranging in age from 9 months to 3 years. In all three cases, there is a downregulation of promoter P1 in the tumor tissues while the P2 and P3 promoters are upregulated compared to the normal liver. One of three patients displayed loss of imprinting (LOI) of IGF2 in...
Topics
- Alleles
- Base Sequence
- Child, Preschool
- Female
- Gene Expression Regulation, Neoplastic
- Genes, Tumor Suppressor
- Genomic Imprinting
- Hepatoblastoma
- Humans
- Infant
- Insulin-Like Growth Factor II