Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Promoter-specific imprinting of the human insulin-like growth factor-II gene.

Nature - 20 Oct 1994

Vu T H, Hoffman A R

Abstract excerpt

Genomic imprinting is a mechanism whereby only one of the two parental alleles is expressed. Loss or relaxation of genomic imprinting has been proposed as an epigenetic mechanism for oncogenesis in a variety of human tumours. Although the mechanism of imprinting is unknown, differential CpG methylation of the parental alleles has been implicated. The human insulin-like growth factor-II (IGF2) gene, which is...

Topics

Adult
Alleles
Base Sequence
Cartilage
DNA Primers
Fetus
Genomic Imprinting
Humans
Insulin-Like Growth Factor II
Liver
Molecular Sequence Data
Polymerase Chain Reaction

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Promoter Regions, Genetic

Source

Identifiers

PMID: 7935819
DOI: 10.1038/371714a0

Genes

IGF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7935819-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Promoter-specific imprinting of the human insulin-like growth factor-II gene.PMID 7935819Read ↗

Promoter-specific insulin-like growth factor 2 gene imprinting in human fetal liver and hepatoblastoma.Semantic proximity Read ↗

Altered transcriptional regulation of the insulin-like growth factor 2 gene in human hepatocellular carcinoma.Semantic proximity Read ↗

Concordant loss of imprinting of the human insulin-like growth factor II gene promoters in cancer.Semantic proximity Read ↗

Promoter-specific IGF2 imprinting status and its plasticity during human liver development.Semantic proximity Read ↗

Developmental regulation of genomic imprinting of the IGF2 gene in human liver.Semantic proximity Read ↗

Disrupted IGF2 promoter control by silencing of promoter P1 in human hepatocellular carcinoma.Semantic proximity Read ↗

Parental imprinting of rat insulin-like growth factor II gene promoters is coordinately regulated.Semantic proximity Read ↗

Promoter-dependent tissue-specific expressive nature of imprinting gene, insulin-like growth factor II, in human tissues.Semantic proximity Read ↗

Imprinting of IGF2 P0 transcript and novel alternatively spliced INS-IGF2 isoforms show differences between mouse and humanSemantic proximity Read ↗

Differential biallelic activation of three insulin-like growth factor II promoters in the mouse central nervous system.Semantic proximity Read ↗

Expression, promoter usage and parental imprinting status of insulin-like growth factor II (IGF2) in human hepatoblastoma: uncoupling of IGF2 and H19 imprinting.Semantic proximity Read ↗

Biallelic expression of all four IGF-II promoters and its association with increased methylation of H19 gene in human brain.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.