Article
Promoter-specific imprinting of the human insulin-like growth factor-II gene.
Nature - 20 Oct 1994
Vu T H, Hoffman A R
Abstract excerpt
Genomic imprinting is a mechanism whereby only one of the two parental alleles is expressed. Loss or relaxation of genomic imprinting has been proposed as an epigenetic mechanism for oncogenesis in a variety of human tumours. Although the mechanism of imprinting is unknown, differential CpG methylation of the parental alleles has been implicated. The human insulin-like growth factor-II (IGF2) gene, which is...
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