Article
Alterations in the promoter-specific imprinting of the insulin-like growth factor-II gene in Wilms' tumor.
The Journal of biological chemistry - 12 Apr 1996
Vu T H, Hoffman A
Abstract excerpt
The human IGF2 gene, which encodes a mitogenic peptide required for normal fetal development, is overexpressed in many types of tumors. IGF2 is transcribed from four promoters (P1-P4), and in most tissues, the gene is imprinted. In this study, we have analyzed IGF2 promoter usage and determined t...
Topics
- Alleles
- Base Sequence
- DNA Primers
- Gene Expression Regulation, Neoplastic
- Genomic Imprinting
- Humans
- Insulin-Like Growth Factor II
- Kidney
- Lung Neoplasms
- Molecular Sequence Data
- Pancreas
- Promoter Regions, Genetic
- RNA, Messenger
- Transcription, Genetic
- Wilms Tumor