Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Alterations in the promoter-specific imprinting of the insulin-like growth factor-II gene in Wilms' tumor.

The Journal of biological chemistry - 12 Apr 1996

Vu T H, Hoffman A

Abstract excerpt

The human IGF2 gene, which encodes a mitogenic peptide required for normal fetal development, is overexpressed in many types of tumors. IGF2 is transcribed from four promoters (P1-P4), and in most tissues, the gene is imprinted. In this study, we have analyzed IGF2 promoter usage and determined the allelic expression from each promoter in 19 ApaI- and 22 AluI-heterozygous Wilms' tumors. Loss of IGF2 imprinting...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Base Sequence
Share to DNA Primers

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Lung Neoplasms

Share to Molecular Sequence Data

Share to Promoter Regions, Genetic

Share to RNA, Messenger

Share to Transcription, Genetic

Source

Identifiers

PMID: 8621549
DOI: 10.1074/jbc.271.15.9014

Genes

IGF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Alterations in the promoter-specific imprinting of the insulin-like growth factor-II gene in Wilms' tumor.PMID 8621549Read ↗

Altered transcriptional regulation of the insulin-like growth factor 2 gene in human hepatocellular carcinoma.Semantic proximity Read ↗

Loss of Imprinting of Insulin-Like Growth Factor-II (IGF2) Gene in Distinguishing Specific Biologic Subtypes of Wilms TumorSemantic proximity Read ↗

Concordant loss of imprinting of the human insulin-like growth factor II gene promoters in cancer.Semantic proximity Read ↗

Loss of imprinting of IGF2 sense and antisense transcripts in Wilms' tumor.Semantic proximity Read ↗

Promoter-specific imprinting of the human insulin-like growth factor-II gene.Semantic proximity Read ↗

Promoter histone H3K27 methylation in the control of IGF2 imprinting in human tumor cell lines.Semantic proximity Read ↗

Aberrant imprinting of the insulin-like growth factor II receptor gene in Wilms' tumor.Semantic proximity Read ↗

Analysis of genomic imprinting of insulin-like growth factor 2 in colorectal cancer.Semantic proximity Read ↗

Genomic imprinting and carcinogenesis.Semantic proximity Read ↗

Relaxation of insulin-like growth factor II gene imprinting implicated in Wilms' tumour.Semantic proximity Read ↗

Expression, promoter usage and parental imprinting status of insulin-like growth factor II (IGF2) in human hepatoblastoma: uncoupling of IGF2 and H19 imprinting.Semantic proximity Read ↗

Genomic Deletion of an Imprint Maintenance Element Abolishes Imprinting of Both Insulin-like Growth Factor II andH19Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.