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Article

p57(KIP2) is not mutated in hepatoblastoma but shows increased transcriptional activity in a comparative analysis of the three imprinted genes p57(KIP2), IGF2, and H19.

The American journal of pathology - 1 Oct 2000

Hartmann W, Waha A, Koch A, Goodyer C G, Albrecht S, von Schweinitz D, Pietsch T

Abstract excerpt

Hepatoblastomas (HBs), representing malignant liver tumors of childhood, show frequent loss of heterozygosity (LOH) in the chromosomal region 11p15.5. This loss is of maternal origin suggesting the presence of a monoallelically expressed tumor suppressor gene in this region. p57(KIP2) (KIP2) located at 11p15.5 is predominantly expressed from the maternal allele and encodes a cyclin-dependent kinase inhibitor. We...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Insulin-Like Growth Factor II

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Source

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Identifiers

PMID: 11021841
DOI: 10.1016/S0002-9440(10)64652-4
PMCID: PMC1850179

Genes

IGF2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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p57(KIP2) is not mutated in hepatoblastoma but shows increased transcriptional activity in a comparative analysis of the three imprinted genes p57(KIP2), IGF2, and H19.PMID 11021841Read ↗

Imprinting of the gene encoding a human cyclin-dependent kinase inhibitor, p57KIP2, on chromosome 11p15.Semantic proximity Read ↗

Human p57(KIP2) defines a new imprinted domain on chromosome 11p but is not a tumour suppressor gene in Wilms tumour.Semantic proximity Read ↗

Loss of imprinting of IGF2 correlates with hypermethylation of the H19 differentially methylated region in hepatoblastomaSemantic proximity Read ↗

Disruption of imprinted genes at chromosome region 11p15.5 in paediatric rhabdomyosarcoma.Semantic proximity Read ↗

Decreased expression of p57KIP2 mRNA in human bladder cancerSemantic proximity Read ↗

Chromosome 11p15.5 regional imprinting: comparative analysis of KIP2 and H19 in human tissues and Wilms' tumors.Semantic proximity Read ↗

Assessment of p57(KIP2) gene mutation in Beckwith-Wiedemann syndrome.Semantic proximity Read ↗

Comparative reverse transcription-polymerase chain reaction and in situ hybridization analyses of human imprinted p57KIP2 and insulin-like growth factor 2 gene transcripts in fetal kidney and Wilms' tumors using archival tissue.Semantic proximity Read ↗

Genomic imprinting of human p57KIP2 and its reduced expression in Wilms' tumors.Semantic proximity Read ↗

Disrupted IGF2 promoter control by silencing of promoter P1 in human hepatocellular carcinoma.Semantic proximity Read ↗

Coding mutations in p57KIP2 are present in some cases of Beckwith-Wiedemann syndrome but are rare or absent in Wilms tumors.Semantic proximity Read ↗

An imprinted gene p57KIP2 is mutated in Beckwith-Wiedemann syndrome.Semantic proximity Read ↗

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