Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Rediscovering ACE: novel insights into the many roles of the angiotensin-converting enzyme.

Journal of molecular medicine (Berlin, Germany) - 1 Oct 2013

Gonzalez-Villalobos Romer A, Shen Xiao Z, Bernstein Ellen A, Janjulia Tea, Taylor Brian, Giani Jorge F, Blackwell Wendell-Lamar B, Shah Kandarp H, Shi Peng D, Fuchs Sebastien, Bernstein Kenneth E

Abstract excerpt

Angiotensin-converting enzyme (ACE) is best known for the catalytic conversion of angiotensin I to angiotensin II. However, the use of gene-targeting techniques has led to mouse models highlighting many other biochemical properties and actions of this enzyme. This review discusses recent studies examining the functional significance of ACE tissue-specific expression and the presence in ACE of two independent...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Endothelial Cells
Share to Histocompatibility Antigens Class I

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Immunity

Share to Immunologic Memory

Share to Kidney

Share to Peptides

Share to Peptidyl-Dipeptidase A

Share to Protein Interaction Domains and Motifs

Source

Open in PubMed Open full text

Identifiers

PMID: 23686164
DOI: 10.1007/s00109-013-1051-z
PMCID: PMC3779503

Genes

ACE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Rediscovering ACE: novel insights into the many roles of the angiotensin-converting enzyme.PMID 23686164Read ↗

New insights into the role of angiotensin-converting enzyme obtained from the analysis of genetically modified mice.Semantic proximity Read ↗

ACE2 mouse models: a toolbox for cardiovascular and pulmonary researchSemantic proximity Read ↗

The emerging role of ACE2 in physiology and diseaseSemantic proximity Read ↗

The critical role of tissue angiotensin-converting enzyme as revealed by gene targeting in mice.Semantic proximity Read ↗

Development and characterization of a fully humanized ACE2 mouse modelSemantic proximity Read ↗

Exploring type I angiotensin (AT<sub>1</sub>) receptor functions through gene targetingSemantic proximity Read ↗

Novel transgenic mice with Cre-dependent co-expression of GFP and human ACE2: a safe tool for study of COVID-19 pathogenesisSemantic proximity Read ↗

The central role of angiotensin I-converting enzyme in vertebrate pathophysiology.Semantic proximity Read ↗

Mice lacking endothelial ACE: normal blood pressure with elevated angiotensin II.Semantic proximity Read ↗

The SARS-CoV-2 receptor ACE2 is expressed in mouse pericytes but not endothelial cells: Implications for COVID-19 vascular researchSemantic proximity Read ↗

Transgenic mice as a tool to study the renin-angiotensin system.Semantic proximity Read ↗

Genetically increased angiotensin I-converting enzyme alters peripheral and renal vascular reactivity to angiotensin II and bradykinin in mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.