Article
Mice lacking endothelial ACE: normal blood pressure with elevated angiotensin II.
Hypertension (Dallas, Tex. : 1979) - 1 Feb 2003
Cole Justin M, Khokhlova Nata, Sutliff Roy L, Adams Jonathan W, Disher Kevin M, Zhao Hui, Capecchi Mario R, Corvol Pierre, Bernstein Kenneth E
Abstract excerpt
Recently, the concept of local renin-angiotensin systems (RAS) capable of generating angiotensin II apart from the circulation has received considerable attention. To investigate this, we generated ACE 1/3 mice in which one allele of ACE is null and the second allele was engineered to express ACE on the surface of hepatocytes. ACE 1/3 mice express no endothelial ACE and lack ACE within the lungs. Their kidneys...
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