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Article

Mice lacking endothelial angiotensin-converting enzyme have a normal blood pressure.

Circulation research - 11 Jan 2002

Cole Justin, Quach Du Le, Sundaram Karthik, Corvol Pierre, Capecchi Mario R, Bernstein Kenneth E

Abstract excerpt

To test the hypothesis that local vascular production of angiotensin II is necessary for the normal regulation of blood pressure, we engineered a new line of genetically altered mice that lack endothelial angiotensin-converting enzyme (ACE). This was accomplished using a novel strategy of targeted homologous recombination to separate the transcriptional control of somatic ACE from its endogenous promoter and to...

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Identifiers

PMID: 11786523
DOI: 10.1161/hh0102.102360

Genes

ACE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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