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Article

ACE2 mouse models: a toolbox for cardiovascular and pulmonary research

14 Oct 2020

Abstract excerpt

Angiotensin-converting enzyme 2 (ACE2) has been identified as the host entry receptor for the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) responsible for the COVID-19 pandemic. ACE2 is a regulatory enzyme of the renin-angiotensin system and has protective functions in many cardiovascular, pulmonary and metabolic diseases. This review summarizes available murine models with systemic or...

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PMID: 33057007
DOI: 10.1038/s41467-020-18880-0

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