Article
Frequency and clinico-pathological associations of ras mutations in colorectal cancer in the Victorian population.
The Australian and New Zealand journal of surgery - 1 May 1997
Thomas R J, Liu Y S, St Clair F, Norris P M, Valentine R, Phillips W A
Abstract excerpt
BACKGROUND: Mutations in the oncogene ras occur in 20-50% of colorectal cancers. The presence of these mutations allows screening tests to be developed based on the identification of mutant DNA in cells derived from cancers. A study of the prevalence and clinicopathological associations of ras mutations was undertaken. METHODS: The frequency of mutations in codons 12 and 13 of the K-ras gene was investigated in...
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