Article
Prevalence of ras gene mutations in human colorectal cancers.
Nature - 1 Jan 2000
Bos J L, Fearon E R, Hamilton S R, Verlaan-de Vries M, van Boom J H, van der Eb A J, Vogelstein B
Abstract excerpt
A combination of DNA hybridization analyses and tissue sectioning techniques demonstrate that ras gene mutations occur in over a third of human colorectal cancers, that most of the mutations are at codon 12 of the c-Ki-ras gene and that the mutations usually precede the development of malignancy.
Topics
- Adenoma
- Carcinoma
- Codon
- Colonic Neoplasms
- DNA
- Humans
- Mutation
- Nucleic Acid Hybridization
- Oncogenes
- Rectal Neoplasms