Article
Activation of c-K-ras mutations in human gastrointestinal tumors.
Gastroenterology - 1 Jun 2000
Arber N, Shapira I, Ratan J, Stern B, Hibshoosh H, Moshkowitz M, Gammon M, Fabian I, Halpern Z
Abstract excerpt
BACKGROUND & AIMS: Ras genes are the most frequently detected oncogenes in human malignancies. Data regarding the frequency of c-K-ras mutations in esophageal, gastric, and small bowel tumors are limited and controversial. METHODS: DNA was extracted from 262 formalin-fixed, paraffin-embedded sect...
Topics
- Adenocarcinoma
- Adenoma
- Alleles
- Barrett Esophagus
- Carcinoma, Squamous Cell
- DNA Mutational Analysis
- Esophageal Neoplasms
- Gastrointestinal Neoplasms
- Genes, ras
- Humans
- Intestinal Neoplasms
- Israel
- New York City
- Point Mutation
- Polymerase Chain Reaction
- Polymorphism, Genetic
- Stomach Neoplasms