Article
Specific codon 13 K-ras mutations are predictive of clinical outcome in colorectal cancer patients, whereas codon 12 K-ras mutations are associated with mucinous histotype.
Annals of oncology : official journal of the European Society for Medical Oncology - 1 Sept 2002
Bazan V, Migliavacca M, Zanna I, Tubiolo C, Grassi N, Latteri M A, La Farina M, Albanese I, Dardanoni G, Salerno S, Tomasino R M, Labianca R, Gebbia N, Russo A
Abstract excerpt
BACKGROUND: K-ras mutations, one of the earliest events observed in colorectal carcinogenesis, are mostly found in codons 12 and 13, and less frequently in codon 61, all three of which are estimated to be critical for the biological activity of the protein. Nevertheless the prognostic significance of such mutations remains controversial. Our purpose was to assess whether any or specific K-ras mutations in primary...
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