Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Constitutive expression of lymphoma-associated NFKB-2/Lyt-10 proteins is tumorigenic in murine fibroblasts.

Oncogene - 17 Apr 1997

Ciana P, Neri A, Cappellini C, Cavallo F, Pomati M, Chang C C, Maiolo A T, Lombardi L

Abstract excerpt

The NFKB-2 (Lyt-10) gene codes for an NF-kappaB-related transcription factor containing rel-polyG-ankyrin domains. Rearrangements of the NFKB-2 locus leading to the production of 3' truncated NFKB-2 proteins are recurrently found in lymphoid neoplasms, particularly cutaneous lymphomas. Such mutant NFKB-2 proteins have lost the ability to repress transcription that is typical of NFKB-2 subunit p52, and function as...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 3T3 Cells
Share to Cell Transformation, Neoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lymphoma

Share to Mice, Inbred BALB C

Share to Mutation

Share to Neoplasm Proteins

Share to Proto-Oncogene Proteins

Source

Identifiers

PMID: 9150386
DOI: 10.1038/sj.onc.1201015

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Constitutive expression of lymphoma-associated NFKB-2/Lyt-10 proteins is tumorigenic in murine fibroblasts.PMID 9150386Read ↗

Myc suppression of Nfkb2 accelerates lymphomagenesisSemantic proximity Read ↗

Constitutive production of NF-kappaB2 p52 is not tumorigenic but predisposes mice to inflammatory autoimmune disease by repressing Bim expression.Semantic proximity Read ↗

The IKK2/NF-κB pathway suppresses MYC-induced lymphomagenesisSemantic proximity Read ↗

Rearranged NF-kappa B2 gene in an adult T-cell leukemia cell line.Semantic proximity Read ↗

NF-kappaB-inducing kinase is dispensable for activation of NF-kappaB in inflammatory settings but essential for lymphotoxin beta receptor activation of NF-kappaB in primary human fibroblasts.Semantic proximity Read ↗

Nuclear Factor (NF)-κB2 (p100/p52) Is Required for Normal Splenic Microarchitecture and B Cell–mediated Immune ResponsesSemantic proximity Read ↗

Secretion of cytokines and growth factors as a general cause of constitutive NFkappaB activation in cancer.Semantic proximity Read ↗

Molecular mechanisms of transcriptional control of bcl-2 and c-myc in follicular and transformed lymphoma.Semantic proximity Read ↗

Synovial fibroblast-like cell transfection with the SV40 large T antigen induces a transformed phenotype and permits transient tumor formation in immunodeficient mice.Semantic proximity Read ↗

A Transgenic Model Reveals Important Roles for the NF-κB Alternative Pathway (p100/p52) in Mammary Development and Links to TumorigenesisSemantic proximity Read ↗

Increased expression of Ifi202, an IFN-activatable gene, in B6.Nba2 lupus susceptible mice inhibits p53-mediated apoptosis.Semantic proximity Read ↗

Tumorigenicity of mouse BALB/c 3T3 fibroblast cells which express Epstein-Barr virus-encoded LMP1 and show normal growth phenotypes in vitro is correlated with loss of transforming growth factor-beta 1-mediated growth inhibition.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.