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Article

Constitutive production of NF-kappaB2 p52 is not tumorigenic but predisposes mice to inflammatory autoimmune disease by repressing Bim expression.

The Journal of biological chemistry - 18 Apr 2008

Wang Zhe, Zhang Baochun, Yang Liqun, Ding Jane, Ding Han-Fei

Abstract excerpt

Normal development of the immune system requires regulated processing of NF-kappaB2 p100 to p52, which activates NF-kappaB2 signaling. Constitutive production of p52 has been suggested as a major mechanism underlying lymphomagenesis induced by NF-kappaB2 mutations, which occur recurrently in a variety of human lymphoid malignancies. To test the hypothesis, we generated transgenic mice with targeted expression of...

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Identifiers

PMID: 18281283
DOI: 10.1074/jbc.M800806200
PMCID: PMC3762532

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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