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Article

Increased expression of Ifi202, an IFN-activatable gene, in B6.Nba2 lupus susceptible mice inhibits p53-mediated apoptosis.

Journal of immunology (Baltimore, Md. : 1950) - 15 May 2006

Xin Hong, D'Souza Sanjay, Jørgensen Trine N, Vaughan Andrew T, Lengyel Peter, Kotzin Brian L, Choubey Divaker

Abstract excerpt

Increased expression of p202 protein (encoded by the Ifi202 gene) in splenocytes derived from B6.Nba2 mice (congenic for the Nba2 interval derived from the New Zealand Black mice) was correlated with defects in apoptosis of splenic B cells and increased susceptibility to develop systemic lupus erythematosus. We have now investigated the molecular mechanisms by which increased expression of p202 in B6.Nba2 cells...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Interferons

Share to Intracellular Signaling Peptides and Proteins

Share to Lupus Erythematosus, Systemic

Share to Mice, Inbred AKR

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Share to Tumor Suppressor Protein p53

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Identifiers

PMID: 16670293
DOI: 10.4049/jimmunol.176.10.5863

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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