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Article

Secretion of cytokines and growth factors as a general cause of constitutive NFkappaB activation in cancer.

Oncogene - 18 Mar 2004

Lu Tao, Sathe Swati S, Swiatkowski Shannon M, Hampole Chetan V, Stark George R

Abstract excerpt

The constitutive activation of nuclear factor kappaB (NFkappaB) helps a variety of tumors to resist apoptosis and desensitizes them to chemotherapy, but the causes are still largely unknown. We have analysed this phenomenon in eight mutant cell lines derived from human 293 cells, selected for NFkappaB-dependent expression of a marker gene, and also in seven tumor-derived cell lines. Conditioned media from all of...

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Identifiers

PMID: 14676835
DOI: 10.1038/sj.onc.1207332

Genes

FGF5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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