Article
Tumorigenicity of mouse BALB/c 3T3 fibroblast cells which express Epstein-Barr virus-encoded LMP1 and show normal growth phenotypes in vitro is correlated with loss of transforming growth factor-beta 1-mediated growth inhibition.
Archives of virology - 1 Jan 1999
Takanashi M, Li J, Shirakata M, Mori S, Hirai K
Abstract excerpt
Latent membrane protein 1 (LMP1) encoded by the Epstein-Barr virus (EBV) genome is known to induce loss of contact inhibition and the anchorage-independent growth in rodent fibroblasts and increased expression of cell-surface activation markers and cell adhesion molecules in human B lymphocytes. To analyze the role of LMP1 in tumorigenicity, we prepared BALB/c 3T3 clones (B3LP) expressing LMP1. These B3LP cells...
Topics
- 3T3 Cells
- Animals
- Cell Division
- Cell Line, Transformed
- Cell Transformation, Neoplastic
- Cell Transformation, Viral
- Fibroblasts
- Gene Expression
- Genes, myc
- Herpesvirus 4, Human
- Humans
- Mice
- Mice, Inbred BALB C