Article
Molecular mechanisms of transcriptional control of bcl-2 and c-myc in follicular and transformed lymphoma.
Cancer research - 1 Jul 2001
Arcinas M, Heckman C A, Mehew J W, Boxer L M
Abstract excerpt
A synergistic interaction of Bcl-2 and c-Myc plays a role in lymphomagenesis in mice and in some patients as well. Progression of follicular lymphoma to a more aggressive lymphoma is seen in the majority of patients, and approximately 10% of the transformed lymphomas have a translocation of c-myc in addition to the translocation of bcl-2 found in the original follicular lymphoma. We investigated whether...
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