Article
Rearranged NF-kappa B2 gene in an adult T-cell leukemia cell line.
Cancer science - 1 Apr 2008
Isogawa Masato, Higuchi Masaya, Takahashi Masahiko, Oie Masayasu, Mori Naoki, Tanaka Yuetsu, Aoyagi Yutaka, Fujii Masahiro
Abstract excerpt
Adult T-cell leukemia (ATL) is an aggressive type of leukemia, originating from T-cells infected with human T-cell leukemia virus type 1. Accumulating evidence suggests the aberrant activation of NF-kappaB to be a causative factor mediating the abnormal proliferation of leukemic cells, thus resulting in the development of ATL. A rearranged NF-kappa B2/p100 gene was isolated from an ATL-derived cell line, which...
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