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Article

The IKK2/NF-κB pathway suppresses MYC-induced lymphomagenesis

24 Jul 2009

Abstract excerpt

Deregulated c-MYC is found in a variety of cancers where it promotes proliferation as well as apoptosis. In many hematologic malignancies, enhanced NF-kappaB exerts prosurvival functions. Here we investigated the role of NF-kappaB in mouse and human c-MYC-transformed lymphomas. The NF-kappaB pathway is extinguished in murine lymphoma cells, and extrinsic stimuli typically inducing NF-kappaB activity fail to...

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Identifiers

PMID: 19628709
DOI: 10.1182/blood-2008-09-181008

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The IKK2/NF-κB pathway suppresses MYC-induced lymphomagenesisPMID 19628709Read ↗

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