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Article

Use of modified functional assays for activated protein C resistance in patients with basally prolonged aPTT.

Thrombosis and haemostasis - 1 Sept 1997

Montaruli B, Schinco P, Pannocchia A, Giorgianni A, Borchiellini A, Tamponi G, Pileri A

Abstract excerpt

Inherited resistance to activated protein C (APCr) is currently recognized as the most prevalent cause underlying venous thrombophilia, with an estimated prevalence around 20% in thrombotic patients and around 1.8-7% in the general population. A correct laboratory diagnosis of APCr is therefore essential. Two different diagnostic approaches are at present at our disposal: the semi-quantitative plasma test based...

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Share to Blood Coagulation Tests
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 9308751

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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A highly specific functional test for factor V leiden: A modified tissue factor assay for activated protein C resistance.Semantic proximity Read ↗

Comparison of three activated protein C resistance tests in the risk assessment of venous thrombosis in non-carriers of the factor V Leiden mutation.Semantic proximity Read ↗

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Determination of activated protein C resistance in anticoagulated and lupus positive patients.Semantic proximity Read ↗

The phenomenon known as acquired activated protein C resistanceSemantic proximity Read ↗

Careful selection of sample dilution and factor-V-deficient plasma makes the modified activated protein C resistance test highly specific for the factor V Leiden mutation.Semantic proximity Read ↗

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