Article
The 1691 G-->A mutation in the factor V gene: relationship to activated protein C (APC) resistance and thrombosis in 65 patients.
Thrombosis and haemostasis - 1 Jan 1996
Leroy-Matheron C, Levent M, Pignon J M, Mendonça C, Gouault-Heilmann M
Abstract excerpt
Four hundred fifty subjects were screened for the 1691 G-->A mutation in the factor V gene. Two hundred ninety-seven patients were referred to us for unexplained thrombosis, 133 were family members of these patients and 20 were normal subjects. We studied the relationships between the mutation, r...
Topics
- Adenine
- Adolescent
- Adult
- Aged
- Case-Control Studies
- Drug Resistance
- Factor V
- Female
- Fibrinolytic Agents
- Guanine
- Humans
- Male
- Middle Aged
- Mutation
- Pedigree
- Phenotype
- Protein C
- Thrombosis