Article
Discrimination between normal wildtype and carriers of coagulation factor V Leiden mutation by the activated protein C resistance test in the presence of factor V deficient plasma.
European journal of clinical chemistry and clinical biochemistry : journal of the Forum of European Clinical Chemistry Societies - 1 Jan 1997
Reuner K H, Litfin F, Patscheke H
Abstract excerpt
Blood samples from 104 patients with clinically suspected thrombophilia were analyzed for coagulation factor V Leiden mutation (1691, G-->A) by allele-specific polymerase chain reaction. In 86 individuals (82.7%), the mutation was not detectable, whereas 15 patients (14.4%) were heterozygous and...
Topics
- Base Sequence
- Blood Coagulation Tests
- DNA Primers
- Factor V
- Factor V Deficiency
- Female
- Genetic Carrier Screening
- Genotype
- Homozygote
- Humans
- Male
- Molecular Sequence Data
- Point Mutation
- Polymerase Chain Reaction
- Protein C
- Reference Values
- Thrombophlebitis